Morpholine → 1-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanone

HRID 385796노트

반응식

HRID 385796 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[N:6]=1)=[O:4].[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>O1CCCC1.CN(C)C=O.C(OCC)(=O)C>[Br:11][C:7]1[N:6]=[C:5]([C:3](=[O:4])[CH2:2][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:10]=[CH:9][CH:8]=1

참가 물질

6

반응물 2

HCID 8083MorpholineHCID 534075852-Bromo-1-(6-bromopyridin-2-yl)ethan-1-one

생성물 1

HCID 595263201-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanone

시약·촉매·용매 3

HCID 6228Dimethylformamide용매HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2-bromo-1-(6-bromopyridin-2-yl)ethanone (250 mg, 0.90 mmol) in tetrahydrofuran (1 mL) and dimethylformamide (1 mL) was added morpholine (0.18 mL, 2.0 mmol). After 45 minutes, the reaction mixture was diluted with ethyl acetate (30 mL) and washed with saturated aqueous sodium bicarbonate (15 mL) and brine (15 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford the title compound.

후처리

  1. washwashed with saturated aqueous sodium bicarbonate (15 mL) and brine (15 mL)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4c1d8ce65b514d8d8625714bfe11e6e3
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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