(2E)-4-(Dimethylamino)-2-butenoic acid hydrochloride → N-(3-Chloro-4-fluorophenyl)-6-[(2E)-4-(dimethylamino)but-2-enoyl]-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

HRID 38581

반응식

HRID 38581 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][NH:20][CH2:21][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8].Cl.[CH3:23][N:24]([CH3:31])[CH2:25]/[CH:26]=[CH:27]/[C:28](O)=[O:29]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:11]3[C:18]4[CH2:19][N:20]([C:28](=[O:29])/[CH:27]=[CH:26]/[CH2:25][N:24]([CH3:31])[CH3:23])[CH2:21][C:17]=4[S:16][C:12]=3[N:13]=[CH:14][N:15]=2)[CH:5]=[CH:6][C:7]=1[F:8]

참가 물질

3

반응물 2

HCID 45358758(2E)-4-(Dimethylamino)-2-butenoic acid hydrochlorideHCID 58116969N-(3-Chloro-4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

생성물 1

HCID 46938197N-(3-Chloro-4-fluorophenyl)-6-[(2E)-4-(dimethylamino)but-2-enoyl]-6,7-dihydro-5H-pyrrolo[3',4':4,5]thieno[2,3-d]pyrimidin-4-amine

실험 절차

In analogy to Example 89, the title compound was prepared from N-(3-chloro-4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 23A (60 mg, 0.19 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (43 mg, 0.26 mmol) to yield 17 mg (21%).

후처리

  1. customto yield 17 mg (21%)

출처 및 근거

ORD 기록
ord-d525c682f61d4633a40da222d24a8e46
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524722B2

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