Tetrabutylammonium Fluoride → (4R)-1-[(6-bromopyridin-2-yl)methyl]-4-hydroxypyrrolidin-2-one
반응식
[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:13][C@H:12]([O:14][Si](C(C)(C)C)(C)C)[CH2:11][C:10]2=[O:22])[CH:5]=[CH:4][CH:3]=1.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[CH2:13][C@H:12]([OH:14])[CH2:11][C:10]2=[O:22])[CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
(4R)-1-[(6-Bromopyridin-2-yl)methyl]-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidin-2-one was dissolved in tetrahydrofuran (33.4 mL), and tetrabutylammonium fluoride (5.84 mL, 5.84 mmol) was added dropwise and the solution stirred at ambient temperature for five minutes. The reaction mixture was concentrated and purified by silica gel chromatography to yield the title compound.
후처리
- concentrationThe reaction mixture was concentrated
- custompurified by silica gel chromatography
출처 및 근거
- ORD 기록
- ord-54d2202d4cfe4e1686764915b555f412
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08367706B2
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