2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-methoxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide
반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][O:10][CH3:11])[N:3]=1.[NH2:12][C:13]1[S:14][C:15]([C:21]2[C:26]([F:27])=[CH:25][C:24]([C:28]([OH:31])([CH3:30])[CH3:29])=[CH:23][C:22]=2[F:32])=[CH:16][C:17]=1[C:18]([NH2:20])=[O:19]>>[F:32][C:22]1[CH:23]=[C:24]([C:28]([OH:31])([CH3:30])[CH3:29])[CH:25]=[C:26]([F:27])[C:21]=1[C:15]1[S:14][C:13]([NH:12][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][CH2:9][O:10][CH3:11])[N:3]=2)=[C:17]([C:18]([NH2:20])=[O:19])[CH:16]=1참가 물질
3
실험 절차
The title compound was prepared according to the general procedure in Example 1 using 2-bromo-6-(2-methoxyethyl)pyridine (42 mg, 0.19 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (60 mg, 0.19 mmol) as the starting materials.
출처 및 근거
- ORD 기록
- ord-d9ccc9775c644fe2bece8de8e2fef57f