반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:16][C:17]2[C:18]3[C:25]4[CH2:26][NH:27][CH2:28][C:24]=4[S:23][C:19]=3[N:20]=[CH:21][N:22]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1.Cl.[CH3:30][N:31]([CH3:38])[CH2:32]/[CH:33]=[CH:34]/[C:35](O)=[O:36]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:16][C:17]2[C:18]3[C:25]4[CH2:26][N:27]([C:35](=[O:36])/[CH:34]=[CH:33]/[CH2:32][N:31]([CH3:38])[CH3:30])[CH2:28][C:24]=4[S:23][C:19]=3[N:20]=[CH:21][N:22]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][N:11]=1참가 물질
3
반응물 2
생성물 1
실험 절차
In analogy to Example 89, the title compound was prepared from N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]-6,7-dihydro-5H-pyrrolo[3′,4′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 31A (38 mg, 0.094 mmol) and (2E)-4-(dimethylamino)but-2-enoic acid hydrochloride from Example 1A (22 mg, 0.13 mmol) to yield 18 mg (37%).
후처리
- customto yield 18 mg (37%)
출처 및 근거
- ORD 기록
- ord-96b21b350d404b05be4a97c3bff8d29b
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08524722B2
연결된 노트
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