돌아가기
Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 385881생성일: 2026년 10월 27일

2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-{[6-(5,6-Dihydroimidazo[1,2-a]pyrazin-7(8H)-ylcarbonyl)pyridin-2-yl]amino}-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

https://huagongshe.com/reaction/385881

반응식

참여 물질

역할이름HCID투입량
반응물2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 58216638—
반응물2-bromo-6-{[(3R)-3-methoxypyrrolidin-1-yl]carbonyl}pyridineHCID 59525609—
생성물2-{[6-(5,6-Dihydroimidazo[1,2-a]pyrazin-7(8H)-ylcarbonyl)pyridin-2-yl]amino}-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525724—

반응 단계

The title compound was prepared as described in Example 1 using 2-bromo-6-{[(3R)-3-methoxypyrrolidin-1-yl]carbonyl}pyridine (200 mg, 0.65 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (192 mg, 0.65 mmol) as starting materials.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08367706B2
출처 데이터셋uspto-grants-2013_02
ORD IDord-c8b6c92f959c49c7b5c00d9c8500ef0c
출처 메모uspto-grants-2013_02