Thionyl Chloride → 4-(2-chloroethyl)-1-methyl-1H-pyrazole

HRID 385888

반응식

HRID 385888 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([CH2:7][CH2:8]O)[CH:4]=[N:3]1.S(Cl)([Cl:12])=O>>[Cl:12][CH2:8][CH2:7][C:5]1[CH:4]=[N:3][N:2]([CH3:1])[CH:6]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 170280762-(1-Methyl-1H-pyrazol-4-yl)ethanol

생성물 1

HCID 595256864-(2-chloroethyl)-1-methyl-1H-pyrazole

실험 절차

To excess thionyl chloride (250 mL) at 0° C. was added 2-(1-methyl-1H-pyrazol-4-yl)ethanol (82 g, 0.651 mol). The reaction mixture was heated to reflux for 15 minutes. The excess thionyl chloride was removed in vacuo and the crude product was purified by recrystallization from EtOH to afford the title compound.

후처리

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 15 minutes
  3. customThe excess thionyl chloride was removed in vacuo
  4. customthe crude product was purified by recrystallization from EtOH

출처 및 근거

ORD 기록
ord-8cf3da863bb44cb5b5e5721caf418352
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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