Methylamine → N-Methyl-2-(1-methyl-1H-pyrazol-4-yl)ethan-1-amine

HRID 385889

반응식

HRID 385889 반응식
Cl[CH2:2][CH2:3][C:4]1[CH:5]=[N:6][N:7]([CH3:9])[CH:8]=1.[CH3:10][NH2:11]>>[CH3:10][NH:11][CH2:2][CH2:3][C:4]1[CH:5]=[N:6][N:7]([CH3:9])[CH:8]=1

참가 물질

3

반응물 2

HCID 6329MethylamineHCID 595256864-(2-chloroethyl)-1-methyl-1H-pyrazole

생성물 1

HCID 51000371N-Methyl-2-(1-methyl-1H-pyrazol-4-yl)ethan-1-amine

실험 절차

To neat 4-(2-chloroethyl)-1-methyl-1H-pyrazole (50 g, 0.24 mol) was added a 25% aqueous solution of methylamine (1.15 L, 7.21 mol). The mixture was placed into an autoclave at 60° C. for 15 h. The resulting mixture was concentrated in vacuo, treated with aqueous solution of NaOH and extracted with DCM. The combined organic layers were concentrated in vacuo and purified by vacuum distillation to afford the title compound. b.p. 89-90° C./2 mm Hg.

후처리

  1. concentrationThe resulting mixture was concentrated in vacuo
  2. additiontreated with aqueous solution of NaOH
  3. extractionextracted with DCM
  4. concentrationThe combined organic layers were concentrated in vacuo
  5. distillationpurified by vacuum distillation

출처 및 근거

ORD 기록
ord-6e4fd895a7144b869cd4b77e9541f4cc
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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