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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 385896생성일: 2026년 10월 26일

2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-{[6-(1-Cyano-3-hydroxypropyl)pyridin-2-yl]amino}-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

https://huagongshe.com/reaction/385896

반응식

참여 물질

역할이름HCID투입량
반응물2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 58216638—
반응물2-(6-Bromopyridin-2-yl)-4-hydroxybutanenitrileHCID 59525574—
생성물2-{[6-(1-Cyano-3-hydroxypropyl)pyridin-2-yl]amino}-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 59525763—

반응 단계

The title compound was prepared according to the procedure described in Example 1 using 2-(6-bromopyridin-2-yl)-4-hydroxybutanenitrile (97 mg, 0.40 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (118 mg, 0.40 mmol) as starting materials.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08367706B2
출처 데이터셋uspto-grants-2013_02
ORD IDord-fdbb22ce9a8149009d4d408a8fddbe0a
출처 메모uspto-grants-2013_02