Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-{[6-(1-Cyanocyclopropyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| 반응물 | 1-(6-Bromopyridin-2-YL)cyclopropanecarbonitrile | HCID 59525675 | — |
| 생성물 | 2-{[6-(1-Cyanocyclopropyl)pyridin-2-yl]amino}-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525572 | — |
반응 단계
The title compound was prepared according to the procedure described in Example 1 using 1-(6-bromopyridin-2-yl)cyclopropanecarbonitrile (107 mg, 0.48 mmol) and 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) as starting materials.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367706B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-ab4cfb6f6dd84022ae903b9934098b2c |
| 출처 메모 | uspto-grants-2013_02 |