2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → HCID 59525747, 화합물
반응식
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][S:30]([CH3:33])(=[O:32])=[O:31])[N:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([CH2:29][S:30]([CH3:33])(=[O:31])=[O:32])[N:24]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1참가 물질
3
실험 절차
The title compound was prepared using the procedure described in Example 1 with 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (0.075 g, 0.24 mmol) and 2-bromo-6-[(methylsulfonyl)methyl]pyridine (0.060 g, 0.24 mmol) as starting materials.
출처 및 근거
- ORD 기록
- ord-32ad0d04a2444dceae7a855d1d659358
- 출처 데이터셋
- uspto-grants-2013_02