1-(6-Bromopyridin-2-yl)-4-methylpiperazine → HCID 59525829, 화합물

HRID 385925노트

반응식

HRID 385925 반응식
[NH2:1][C:2]1[S:3][C:4]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:17]([OH:20])([CH3:19])[CH3:18])=[CH:12][C:11]=2[F:21])=[CH:5][C:6]=1[C:7]([NH2:9])=[O:8].Br[C:23]1[N:28]=[C:27]([N:29]2[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]2)[CH:26]=[CH:25][CH:24]=1>>[F:16][C:15]1[CH:14]=[C:13]([C:17]([OH:20])([CH3:18])[CH3:19])[CH:12]=[C:11]([F:21])[C:10]=1[C:4]1[S:3][C:2]([NH:1][C:23]2[CH:24]=[CH:25][CH:26]=[C:27]([N:29]3[CH2:30][CH2:31][N:32]([CH3:35])[CH2:33][CH2:34]3)[N:28]=2)=[C:6]([C:7]([NH2:9])=[O:8])[CH:5]=1

참가 물질

3

반응물 2

HCID 193868331-(6-Bromopyridin-2-yl)-4-methylpiperazineHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

생성물 1

HCID 59525829HCID 59525829, 화합물

실험 절차

The title compound was prepared according to the procedure described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide and 1-(6-bromopyridin-2-yl)-4-methylpiperazine as the starting materials.

출처 및 근거

ORD 기록
ord-4aebbde5ef2b4d129a0e062d0d9c91ca
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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