N'-Acetyl-6-chloronicotinohydrazide → 2-Chloro-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyridine
반응식
[C:1]([NH:4][NH:5][C:6](=[O:14])[C:7]1[CH:12]=[CH:11][C:10]([Cl:13])=[N:9][CH:8]=1)(=O)[CH3:2]>O1CCCC1.C(OCC)(=O)C>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:6]2[O:14][C:1]([CH3:2])=[N:4][N:5]=2)=[CH:8][N:9]=1참가 물질
4
반응 조건
- 온도
- 120 °C
실험 절차
N′-Acetyl-6-chloronicotinohydrazide (95 mg, 0.45 mml) and 3,3,3-triethyl-1-(methoxycarbonyl)diazathian-3-ium-1-ide 2,2-dioxide (159 mg, 0.67 mmol) were taken up in tetrahydrofuran (4.5 mL) and heated in a microwave at 120° C. for 30 minutes. The reaction was then diluted with ethyl acetate and washed with saturated aqueous ammonium chloride, water, and brine. The organic layer was dried over magnesium sulfate, filtered, and concentrated in vacuo to afford the title compound.
후처리
- washwashed with saturated aqueous ammonium chloride, water, and brine
- dry with materialThe organic layer was dried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-6242391d419e4126bb559c3fab22538d
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08367706B2
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