m-Chloroperbenzoic acid → Methyl 2-methylnicotinate 1-oxide

HRID 385949

반응식

HRID 385949 반응식
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.C1C=C(Cl)C=C(C(OO)=[O:20])C=1>C(Cl)Cl>[CH3:1][C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=[CH:4][N+:3]=1[O-:20]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 7015327Methyl 2-methylnicotinate

생성물 1

HCID 20163965Methyl 2-methylnicotinate 1-oxide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methyl 2-methylpyridine-3-carboxylate (10 g, 66.2 mmol) was taken up in DCM (140 mL) and mCPBA (16.31 g, 72.8 mmol) was added. The resulting mixture was allowed to react at room temperature overnight and then purified directly by silica gel chromatography (0-20% MeOH-EtOAc) to afford the title compound as a beige solid.

후처리

  1. customto react at room temperature overnight
  2. custompurified directly by silica gel chromatography (0-20% MeOH-EtOAc)

출처 및 근거

ORD 기록
ord-256fc36ad7554edebbbcc4d54d39a313
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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