m-Chloroperbenzoic acid → 2-(Chloromethyl)-3-(methoxycarbonyl)pyridine 1-oxide

HRID 385951

반응식

HRID 385951 반응식
[Cl:1][CH2:2][C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=[CH:5][N:4]=1.C1C=C(Cl)C=C(C(OO)=[O:21])C=1>C(Cl)Cl>[Cl:1][CH2:2][C:3]1[C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=[CH:5][N+:4]=1[O-:21]

참가 물질

4

반응물 2

HCID 70297m-Chloroperbenzoic acidHCID 19081344Methyl 2-(chloromethyl)pyridine-3-carboxylate

생성물 1

HCID 582166522-(Chloromethyl)-3-(methoxycarbonyl)pyridine 1-oxide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Methyl 2-(chloromethyl)pyridine-3-carboxylate (4.45 g, 23.98 mmol) was taken up in DCM (50 mL) and mCPBA (5.91 g, 26.4 mmol) was added. The resulting solution was allowed to react at room temperature overnight and then purified directly by silica gel chromatography (0-20% MeOH-EtOAc) to afford the title compound as a white solid.

후처리

  1. customto react at room temperature overnight
  2. custompurified directly by silica gel chromatography (0-20% MeOH-EtOAc)

출처 및 근거

ORD 기록
ord-29ea455b19d04b06ba3df77bb0ea3256
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

연결된 노트

불러오는 중…