Hydrazine → 6-Chloro-2-methylnicotinohydrazide

HRID 385965노트

반응식

HRID 385965 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[C:4]([CH3:11])[N:3]=1.[NH2:12][NH2:13]>C(O)C>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH:12][NH2:13])=[O:7])=[C:4]([CH3:11])[N:3]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 462238396-Chloro-2-methylpyridine-3-carboxylic acid

생성물 1

HCID 595262086-Chloro-2-methylnicotinohydrazide

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

6-Chloro-2-methylnicotinic acid (Example 425, Step 1) (480 mg, 2.59 mmol) was taken up in ethanol (5.2 ml). Hydrazine (0.8 ml, 12.93 mmol) was added and the reaction was heated to 80° C. overnight. It was then concentrated under reduced pressure and purified via silica gel chromatography (0-3% methanol in ethyl acetate) to yield the title compound.

후처리

  1. concentrationIt was then concentrated under reduced pressure
  2. custompurified via silica gel chromatography (0-3% methanol in ethyl acetate)

출처 및 근거

ORD 기록
ord-a1171008c2dd4f439d6475d347bd0f01
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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