1,1'-Carbonyldiimidazole → HCID 59526324, 화합물

HRID 385966노트

반응식

HRID 385966 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[C:4]([CH3:12])[N:3]=1.[C:13](N1C=CN=C1)(N1C=CN=C1)=[O:14]>CN(C)C=O.C(OCC)(=O)C>[Cl:1][C:2]1[N:3]=[C:4]([CH3:12])[C:5]([C:6]2[O:7][C:13](=[O:14])[NH:9][N:8]=2)=[CH:10][CH:11]=1

참가 물질

5

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 595262086-Chloro-2-methylnicotinohydrazide

생성물 1

HCID 59526324HCID 59526324, 화합물

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

6-Chloro-2-methylnicotinohydrazide (60 mg, 0.32 mmol) and 1,1′-carbonylbis(1H-imidazole) (58 mg, 0.36 mmol) were taken up in dimethylformamide (1.6 ml). The reaction was heated overnight to 60° C. It was then allowed to cool to room temperature, taken up in ethyl acetate, and washed with water. The organic layer was concentrated under reduced pressure to afford the title compound.

후처리

  1. temperatureThe reaction was heated overnight to 60° C
  2. washwashed with water
  3. concentrationThe organic layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5fe1a4378f904037b7d8f81c20a2376a
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

반응 노트

불러오는 중…