Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → tert-Butyl 3-carbamoylmorpholine-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 4-(tert-Butoxycarbonyl)morpholine-3-carboxylic acid | HCID 2760133 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | tert-Butyl 3-carbamoylmorpholine-4-carboxylate | HCID 21098189 | — |
반응 단계
4-{[(1,1-Dimethylethyl)oxy]carbonyl}morpholine-3-carboxylic acid (0.5 g, 2.162 mmol), ammonium chloride (0.347 g, 6.49 mmol), EDC (0.622 g, 3.24 mmol), HOBt (0.993 g, 6.49 mmol) and DIPEA (1.699 mL, 9.73 mmol) were stirred in DMF (10 mL) at room temperature overnight. Saturated NaHCO3 was then added and the mixture was extracted with EtOAc (2×). The combined organic extracts were washed with brine, dried over MgSO4, filtered, and concentrated in vacuo to give the title compound as a yellow gum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367706B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-12587f8de4164529bd243ea643c98784 |
| 출처 메모 | uspto-grants-2013_02 |