Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(3-hydroxy-3-methylbut-1-yn-1-yl)pyridin-2-yl]amino}thiophene-3-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide | HCID 59525619 | — |
| 반응물 | 4-(6-Bromopyridin-2-yl)-2-methylbut-3-yn-2-ol | HCID 59525879 | — |
| 생성물 | 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(3-hydroxy-3-methylbut-1-yn-1-yl)pyridin-2-yl]amino}thiophene-3-carboxamide | HCID 59526135 | — |
반응 단계
The title compound was prepared as described in Example 1 using 2-amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (150 mg, 0.48 mmol) and 4-(6-bromopyridin-2-yl)-2-methylbut-3-yn-2-ol (115 mg, 0.48 mmol) as starting materials.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367706B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-58b7d5f2b836427ca044f4c4bd184242 |
| 출처 메모 | uspto-grants-2013_02 |