Bis(2-Methoxyethyl)amine → 3-[(7-{(2E)-4-[Bis(2-methoxyethyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-yl)amino]-5-chlorophenol

HRID 38605

반응식

HRID 38605 반응식
Br[CH2:2]/[CH:3]=[CH:4]/[C:5]([OH:7])=O.Cl.[Cl:9][C:10]1[CH:11]=[C:12]([OH:30])[CH:13]=[C:14]([NH:16][C:17]2[C:18]3[C:25]4[CH2:26][CH2:27][NH:28][CH2:29][C:24]=4[S:23][C:19]=3[N:20]=[CH:21][N:22]=2)[CH:15]=1.[CH3:31][O:32][CH2:33][CH2:34][NH:35][CH2:36][CH2:37][O:38][CH3:39]>>[CH3:31][O:32][CH2:33][CH2:34][N:35]([CH2:36][CH2:37][O:38][CH3:39])[CH2:2]/[CH:3]=[CH:4]/[C:5]([N:28]1[CH2:27][CH2:26][C:25]2[C:18]3[C:17]([NH:16][C:14]4[CH:13]=[C:12]([OH:30])[CH:11]=[C:10]([Cl:9])[CH:15]=4)=[N:22][CH:21]=[N:20][C:19]=3[S:23][C:24]=2[CH2:29]1)=[O:7]

참가 물질

4

반응물 3

HCID 2383Bis(2-Methoxyethyl)amineHCID 64364114-Bromocrotonic acidHCID 668500883-Chloro-5-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride

생성물 1

HCID 252209963-[(7-{(2E)-4-[Bis(2-methoxyethyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-yl)amino]-5-chlorophenol

실험 절차

In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (84 mg, 0.41 mmol), 3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 65A (100 mg, 0.27 mmol) and bis(2-methoxyethyl)amine (58 mg, 0.43 mmol) to yield 42 mg (29%).

후처리

  1. customto yield 42 mg (29%)

출처 및 근거

ORD 기록
ord-a731645c2cd54c2f9973f27c46c94efe
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524722B2

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