Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
n,n-Dimethylpiperazine-1-carboxamide → 4-[(2E)-4-{4-[(3-Chloro-5-hydroxyphenyl)amino]-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]-pyrimidin-7(6H)-yl}-4-oxobut-2-en-1-yl]-N,N-dimethylpiperazine-1-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | n,n-Dimethylpiperazine-1-carboxamide | HCID 712909 | — |
| 반응물 | 4-Bromocrotonic acid | HCID 6436411 | — |
| 반응물 | 3-Chloro-5-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride | HCID 66850088 | — |
| 생성물 | 4-[(2E)-4-{4-[(3-Chloro-5-hydroxyphenyl)amino]-5,8-dihydropyrido[4',3':4,5]thieno[2,3-d]-pyrimidin-7(6H)-yl}-4-oxobut-2-en-1-yl]-N,N-dimethylpiperazine-1-carboxamide | HCID 58116972 | — |
반응 단계
In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (84 mg, 0.41 mmol), 3-chloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 65A (100 mg, 0.27 mmol) and N,N-dimethylpiperazine-1-carboxamide (68 mg, 0.43 mmol) to yield 59 mg (38%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524722B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-1ba13dacd352496a8ab6b199f4a36e8f |
| 출처 메모 | uspto-grants-2013_09 |