Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-Methyl-tert-butylamine → 5-[(7-{(2E)-4-[tert-Butyl(methyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-yl)amino]-2,3-dichlorophenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-Methyl-tert-butylamine | HCID 84552 | — |
| 반응물 | 4-Bromocrotonic acid | HCID 6436411 | — |
| 반응물 | 2,3-Dichloro-5-(5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride | HCID 66849887 | — |
| 생성물 | 5-[(7-{(2E)-4-[tert-Butyl(methyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-yl)amino]-2,3-dichlorophenol | HCID 58116936 | — |
반응 단계
The compound was synthesized in analogy to Example 147 from 2,3-dichloro-5-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol hydrochloride from Example 69A (85 mg, 0.21 mmol), (2E)-4-bromobut-2-enoic acid (52 mg, 0.32 mmol) and tert-butyl methylamine (29 mg, 0.34 mmol) to yield 18 mg (16%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524722B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-f68b9af63e934509ad31c4d9f290cfe3 |
| 출처 메모 | uspto-grants-2013_09 |