6-Bromopyridine-2-carbaldehyde → 6-bromopyridine-2-carbaldehyde O-(2-hydroxy-2-methylpropyl)oxime

HRID 386121노트

반응식

HRID 386121 반응식
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.Cl.[NH2:11][O:12][CH2:13][C:14]([CH3:17])([OH:16])[CH3:15]>C(O)C.C(OCC)(=O)C>[OH:16][C:14]([CH3:17])([CH3:15])[CH2:13][O:12][N:11]=[CH:8][C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[N:7]=1

참가 물질

5

반응물 2

HCID 27570096-Bromopyridine-2-carbaldehydeHCID 231323651-(Aminooxy)-2-methylpropan-2-ol hydrochloride

생성물 1

HCID 866462866-bromopyridine-2-carbaldehyde O-(2-hydroxy-2-methylpropyl)oxime

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 6-bromopyridine-2-carbaldehyde (334 mg, 1.80 mmol) and 1-(aminooxy)-2-methylpropan-2-ol hydrochloride salt (254.6 mg, 1.80 mmol) were stirred in ethanol (5 ml) for one hour at 10° C. The reaction mixture was cooled to room temperature and diluted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Column chromatography from 100% hexanes to 30% ethyl acetate afforded the title compound as E/Z mixture.

후처리

  1. washThe organic layer was washed with water
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-a97deab2865842c3bf18d98b09f58e49
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367706B2

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