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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 386122생성일: 2026년 10월 26일

2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-hydroxy-1-methylethyl)pyridazin-3-yl]amino}thiophene-3-carboxamide

https://huagongshe.com/reaction/386122

반응식

참여 물질

역할이름HCID투입량
반응물2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 58216638—
반응물2-(6-Chloropyridazin-3-yl)propan-2-olHCID 59526161—
생성물5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1-hydroxy-1-methylethyl)pyridazin-3-yl]amino}thiophene-3-carboxamideHCID 59525859—

반응 단계

The title compound was prepared by using the procedure listed in Example 1 with starting materials 2-(6-chloropyridazin-3-yl)propan-2-ol (Intermediate 45) (117 mg, 0.68 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (200 mg, 0.68 mmol).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08367706B2
출처 데이터셋uspto-grants-2013_02
ORD IDord-9c87e8e43b5343138ba63c401fc048ec
출처 메모uspto-grants-2013_02