Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromocrotonic acid → 8-{(2E)-4-[Cyclopropyl(methyl)amino]but-2-enoyl}-N-(3,4-dichlorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-c]azepin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromocrotonic acid | HCID 6436411 | — |
| 반응물 | N-Methylcyclopropanamine | HCID 11029756 | — |
| 반응물 | N-(3,4-Dichlorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-c]azepin-4-amine | HCID 58116941 | — |
| 생성물 | 8-{(2E)-4-[Cyclopropyl(methyl)amino]but-2-enoyl}-N-(3,4-dichlorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5',4':4,5]thieno[2,3-c]azepin-4-amine | HCID 25220993 | — |
반응 단계
In analogy to Example 130, the title compound was prepared from (2E)-4-bromobut-2-enoic acid (127 mg, 0.62 mmol), N-(3,4-dichlorophenyl)-6,7,8,9-tetrahydro-5H-pyrimido[5′,4′:4,5]thieno[2,3-c]azepin-4-amine from Example 82A (150 mg, 0.41 mmol) and N-methylcyclopropanamine (116 mg, 1.63 mmol) to yield 21 mg (10%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524722B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-8f5fca2e8f3b44728c6d2cc1c9ec8754 |
| 출처 메모 | uspto-grants-2013_09 |