Ammonium Chloride → 3-(trans-4-(trans-4-Propylcyclohexyl)cyclohexyl)propanol

HRID 386329노트

반응식

HRID 386329 반응식
C([O:3][C:4](=O)[CH2:5][CH2:6][CH:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[CH2:18][CH2:17][CH:16]([CH2:19][CH2:20][CH3:21])[CH2:15][CH2:14]2)[CH2:9][CH2:8]1)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].[Cl-].[NH4+]>C1COCC1>[CH2:19]([CH:16]1[CH2:17][CH2:18][CH:13]([CH:10]2[CH2:11][CH2:12][CH:7]([CH2:6][CH2:5][CH2:4][OH:3])[CH2:8][CH2:9]2)[CH2:14][CH2:15]1)[CH2:20][CH3:21]

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 21226445Aluminium lithium hydrideHCID 592890743-(4'-Propyl-bicyclohexyl-4-yl)-propionic acid ethyl ester

생성물 1

HCID 184179123-(trans-4-(trans-4-Propylcyclohexyl)cyclohexyl)propanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 3-(4′-Propyl-bicyclohexyl-4-yl)-propionic acid ethyl ester (22.0 g, 70 mmol) in THF (150 ml) is added dropwise to a suspension of lithium-aluminiumhydride (3.25 g, 86 mmol) in THF (250 ml) at reflux temperature. The reaction is heated under reflux for 1 h, cooled and poured onto sat. ammonium chloride solution. The mixture is acidified, extracted with ether and the combined organic layers are washed with brine and dried over sodium sulfate. The solvent is evaporated and the crude product is crystallised from isopropanol to give 3-(4′-propyl-bicyclohexyl-4-yl)-propan-1-ol as colourless crystals.

후처리

  1. temperatureat reflux temperature
  2. temperatureThe reaction is heated
  3. temperatureunder reflux for 1 h
  4. temperaturecooled
  5. extractionextracted with ether
  6. washthe combined organic layers are washed with brine
  7. dry with materialdried over sodium sulfate
  8. customThe solvent is evaporated
  9. customthe crude product is crystallised from isopropanol

출처 및 근거

ORD 기록
ord-a1f6099a371442c29f7e4c271bf169bf
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372307B2

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