p-Toluenesulfonic acid → HCID 59289068, 화합물

HRID 386335

반응식

HRID 386335 반응식
[CH2:1]([CH:4]1[CH2:9][CH2:8][CH:7]([C:10]([OH:12])=[O:11])[CH2:6][CH2:5]1)[CH2:2][CH3:3].[Br:13][CH2:14][CH2:15][CH2:16][CH2:17]O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][O:11][C:10]([CH:7]1[CH2:8][CH2:9][CH:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6]1)=[O:12]

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 1183884-BromobutanolHCID 1490324(1s,4r)-4-Propylcyclohexane-1-carboxylic acid

생성물 1

HCID 59289068HCID 59289068, 화합물

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

4-Propyl-cyclohexanecarboxylic acid (10.0 g, 58.0 mmol), 4-bromobutan-1-ol (9.2 g, 60.0 mmol) and a catalytic amount of para-toluene sulphonic acid are stirred under reflux in toluene (300 ml) in a flask equipped with Dean-Stark apparatus over night. The solution is allowed to cool to room temperature, is washed with aqueous sodium carbonate and water, dried and evaporated to dryness. Purification is achieved by flash column chromatography using petrol as eluant. Evaporation of the appropriate fractions gives 4-propyl-cyclohexanecarboxylic acid 4-bromo-butyl ester as the product. The structure is confirmed by 1H NMR spectroscopy and GCMS.

후처리

  1. customequipped with Dean-Stark apparatus over night
  2. washis washed with aqueous sodium carbonate and water
  3. customdried
  4. customevaporated to dryness
  5. customPurification
  6. customEvaporation of the appropriate fractions

출처 및 근거

ORD 기록
ord-e569159be1f043a180086ddbee91d01a
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372307B2

연결된 노트

불러오는 중…