Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrazole → 1-(naphthalen-1-yl)-1H-pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrazole | HCID 1048 | — |
| 반응물 | 1-Iodonaphthalene | HCID 7004 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(naphthalen-1-yl)-1H-pyrazole | HCID 647305 | — |
반응 단계
A mixture of 1H-pyrazole (300 mg, 4.4 mmol), iodonaphthalene (1.1 g, 4.4 mmol), copper (I) iodide (126 mg, 0.66 mmol), Cs2CO3 (2.15 g, 6.6 mmol) in DMF (5 mL) was evacuated and filled with nitrogen twice. The reaction was then stirred at room temperature for 30 minutes and then at 120° C. for 2 days. The reaction mixture was then cooled to room temperature, diluted with ethyl acetate, filtered through silica gel and concentrated to give 1-(naphthalen-1-yl)-1H-pyrazole as pure solid. (800 mg, 93%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08372807B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-bd1102cf020049879ce49d89a44449ac |
| 출처 메모 | uspto-grants-2013_02 |