참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | HCID 178470035 | HCID 178470035 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | HCID 178516647 | HCID 178516647 | 99.5% |
반응 단계
2,4-Dihydroxy-6-trifluoromethyl-nicotinic acid ethyl ester (62 g/247 mmol) was added in several portions over 30 min to 6M HCl(aq) (620 mL) at reflux. Heated at 100° C. overnight with vigorous stirring to obtain complete solution. Allowed to cool and concentrated in vacuo to a white solid. Slurried in water (250 mL) and adjusted to pH 7 with concentrated ammonia to get heavy white suspension. Collected solid by filtration, rinsing through with fresh water, and dried to provide 6-trifluoromethyl-pyridine-2,4-diol (44.0 g) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08372836B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_02 |
|---|
| ORD ID | ord-6c6927a6d71946c8831a739cf18d1414 |
|---|
| 출처 메모 | uspto-grants-2013_02 |
|---|
