Sodium Azide → 5-Azidopentanoic acid ethyl ester

HRID 386421노트

반응식

HRID 386421 반응식
Br[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[N-:11]=[N+:12]=[N-:13].[Na+]>CN(C)C=O.O>[N:11]([CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])=[N+:12]=[N-:13]

참가 물질

5

반응물 2

HCID 33557Sodium AzideHCID 84580Ethyl 5-bromovalerate

생성물 1

HCID 123821765-Azidopentanoic acid ethyl ester수율 95%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

Ethyl 5-bromovalerate (2.1 g; 10 mmol; Aldrich) was added to a stirred suspension of sodium azide (1.3 g, 20 mmol; Fisher) in 5 ml dimethylformamide and 5 ml water, and the reaction mixture was heated 12 h at 80° Cs. The reaction was partitioned between diethyl ether (100 ml) and water (100 ml), and the resulting organic layer was washed with water (100 ml) and brine (100 ml), dried over sodium sulfate, and dried in vacuo. Yield: 1.6 g (9.3 mmol, 95% yield).

후처리

  1. temperaturethe reaction mixture was heated 12 h at 80° Cs
  2. customThe reaction was partitioned between diethyl ether (100 ml) and water (100 ml)
  3. washthe resulting organic layer was washed with water (100 ml) and brine (100 ml)
  4. dry with materialdried over sodium sulfate
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-ebf09f29840241ea95cb9dc7b6c8384b
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372839B2

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