Dichloromethane → 4,5-Bis(chloromethyl)-2H-1,3-benzodioxole

HRID 386524노트

반응식

O[CH2:2][C:3]1[C:11]2[O:10][CH2:9][O:8][C:7]=2[CH:6]=[CH:5][C:4]=1CO.S(Cl)([Cl:16])=O.[CH2:18]([Cl:20])Cl>>[Cl:16][CH2:2][C:3]1[C:11]2[O:10][CH2:9][O:8][C:7]=2[CH:6]=[CH:5][C:4]=1[CH2:18][Cl:20]

참가 물질

반응물 3

HCID 6344Dichloromethane

HCID 24386Thionyl Chloride

HCID 596054HCID 596054, 화합물

생성물 1

HCID 161004004,5-Bis(chloromethyl)-2H-1,3-benzodioxole

실험 절차

A 0° C. solution of (4-hydroxymethyl-1,3-benzodioxol-5-yl)methanol (8.55 g, 47.0 mmoles) from Example 58A in anhydrous methylene chloride (50 mL) was treated dropwise with thionyl chloride (17 mL, 235 mmoles). The mixture was stirred one hour at room temperature and then concentrated under reduced pressure to afford the title compound. MS (DCI) m/z 218 (M+H)+.

후처리

concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록: ord-74c6da05d8c1496ca81502230a1f3db0
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08372841B2

반응 노트

불러오는 중…