Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → 3-Chloro-4-(piperazin-1-yl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Chloro-4-fluorobenzonitrile | HCID 145525 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-Chloro-4-(piperazin-1-yl)benzonitrile | HCID 19367113 | — |
반응 단계
A solution of 3-chloro-4-fluoro-benzonitrile (236 mg, 1.52 mmoles), piperazine (784 mg, 9.1 mmoles) and potassium carbonate (276 mg, 2 mmoles) in acetonitrile (5 mL) was heated to 100° C. overnight. The mixture was cooled, filtered and the filtrate concentrated under reduced pressure. The crude residue was purified by column chromatography (silica gel, 0-5% 2N methanolic ammonia in DCM) to provide the title compound. MS(APCI+) m/z 222 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08372841B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-33e105e4e80148a6aee6147e3a665670 |
| 출처 메모 | uspto-grants-2013_02 |