Thionyl Chloride → 3-(Benzyloxy)-5-methoxybenzoyl chloride

HRID 38657

반응식

HRID 38657 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([O:18][CH3:19])[CH:17]=1)[C:12](O)=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>C1(C)C=CC=CC=1.CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:15]=[C:16]([O:18][CH3:19])[CH:17]=1)[C:12]([Cl:22])=[O:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 126587813-(Benzyloxy)-5-methoxybenzoic acid

생성물 1

HCID 126587833-(Benzyloxy)-5-methoxybenzoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 1140Toluene용매

실험 절차

3-(Benzyloxy)-5-methoxybenzoic acid (162) (2.57 g, 0.01 mmol) and thionyl chloride (4.80 g, 0.04 mmol) were suspended in 200 mL of dry toluene. The reaction mixture was stirred for 30 min and then dimethyl formamide (3 drops) was added. The mixture was stirred for 24 h and then evaporated to dryness. The residue was directly used for the next step without further purification.

후처리

  1. stirringThe mixture was stirred for 24 h
  2. customevaporated to dryness
  3. customThe residue was directly used for the next step without further purification

출처 및 근거

ORD 기록
ord-3c9d93c5e3544b2ab3e9203f54d79d47
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524740B2

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