2,2,2-Trifluoroethanol → 4-(4-(2,6-dimethyl-4-(pyridin-4-yl)phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)benzonitrile

HRID 386646노트

반응식

HRID 386646 반응식
F[C:2](F)(F)C(O)=O.[CH3:8][C:9]1[CH:25]=[C:24]([C:26]2[CH:31]=[CH:30][N:29]=[CH:28][CH:27]=2)[CH:23]=[C:22]([CH3:32])[C:10]=1[O:11][C:12]1[C:13]2N[N:20]=[N:19][C:14]=2[N:15]=[C:16](Cl)[N:17]=1.[NH2:33][C:34]1[CH:41]=[CH:40][C:37]([C:38]#[N:39])=[CH:36][CH:35]=1.FC(F)(F)CO>>[CH3:8][C:9]1[CH:25]=[C:24]([C:26]2[CH:27]=[CH:28][N:29]=[CH:30][CH:31]=2)[CH:23]=[C:22]([CH3:32])[C:10]=1[O:11][C:12]1[N:17]=[C:16]([NH:33][C:34]2[CH:41]=[CH:40][C:37]([C:38]#[N:39])=[CH:36][CH:35]=2)[N:15]=[C:14]2[NH:19][N:20]=[CH:2][C:13]=12

참가 물질

5

반응물 4

HCID 64092,2,2-TrifluoroethanolHCID 6422Trifluoroacetic acidHCID 133964-AminobenzonitrileHCID 178422825HCID 178422825, 화합물

생성물 1

HCID 441239894-(4-(2,6-dimethyl-4-(pyridin-4-yl)phenoxy)-1H-pyrazolo[3,4-d]pyrimidin-6-ylamino)benzonitrile

반응 조건

온도
90 °C

실험 절차

Trifluoroacetic acid (8 eq) is added to a suspension of 7-(2,6-dimethyl-4-(pyridin-4-yl)phenoxy)-5-chloro-1H-[1,2,3]triazolo[4,5-d]pyrimidine (1 eq) and 4-aminobenzonitrile (4 eq) in 2,2,2-trifluoroethanol (1 ml/0.1 mmol) in a sealed tube. The resulting mixture is heated at 90° C. for 3 days. The reaction is cooled to room temperature, concentrated to dryness and purified by silica gel chromatography.

후처리

  1. temperatureThe reaction is cooled to room temperature
  2. concentrationconcentrated to dryness
  3. custompurified by silica gel chromatography

출처 및 근거

ORD 기록
ord-6f5a18608c6e494c95a1b72620d8c01c
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372852B2

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