Chlorosuccinimide → HCID 46218813, 화합물
반응식
[Cl:1]N1C(=O)CCC1=O.[O:9]1[CH2:14][CH2:13][CH:12]([C:15]2[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][C:16]=2[OH:22])[CH2:11][CH2:10]1>ClCCl>[Cl:1][C:19]1[CH:20]=[C:15]([CH:12]2[CH2:11][CH2:10][O:9][CH2:14][CH2:13]2)[C:16]([OH:22])=[CH:17][C:18]=1[OH:21]참가 물질
4
실험 절차
2.4 g of N-chlorosuccinimide are added to a solution of 2 g of 4-(tetrahydropyran-4-yl)benzene-1,3-diol (Example 1) in 30 ml of dichloromethane at 0° C. The reaction mixture is stirred at ambient temperature for 16 hours. The reaction mixture is extracted with dichloromethane and then washed with water. The organic phases are combined and then dried over sodium sulphate. The residue is chromatographed on silica gel (75/25 heptane/ethyl acetate). 400 mg of 4-chloro-6-(tetrahydropyran-4-yl)benzene-1,3-diol are obtained. Yield=17%.
후처리
- extractionThe reaction mixture is extracted with dichloromethane
- washwashed with water
- dry with materialdried over sodium sulphate
- customThe residue is chromatographed on silica gel (75/25 heptane/ethyl acetate)
출처 및 근거
- ORD 기록
- ord-927ece7fa95d4b21af35b319ba63e514
- 출처 데이터셋
- uspto-grants-2013_02
- 특허 번호
- US08372879B2
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