Methylamine → HCID 59253237, 화합물

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[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[O:12][N:11]=[C:10]([C:13]([CH3:17])([CH3:16])[CH:14]=O)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:19][NH2:20].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C>C1COCC1>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[O:12][N:11]=[C:10]([C:13]([CH3:17])([CH3:16])[CH2:14][NH:20][CH3:19])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

실험 절차

[3-(1,1-Dimethyl-2-oxo-ethyl)-isoxazol-5-yl]-carbamic acid tert-butyl ester (150.0 mg, 0.59 mmol) is dissolved in THF (1.0 mL) and 2M methylamine in THF (0.35 mL, 0.71 mmol) is added followed by the addition of MP-triacetoxyborohydride (546.0 mg, 2.70 mmol/g). The reaction mixture is placed on a shaker for 2 h. After this time, the reaction mixture is filtered and the filtrate is concentrated under reduced pressure to provide 163.0 mg of the title compound which is used crude for the next step. m/z 270 [M+H].