Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2,4-Xylyl)piperazine → 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propanal | HCID 86639916 | — |
| 생성물 | 1-(3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propyl)-4-(2,4-dimethylphenyl)piperazine | HCID 25064644 | — |
반응 단계
99 mg (68%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-5-phenyl-1H-pyrazol-3-yl)propanal (80 mg, 0.312 mmol), 1-(2,4-dimethylphenyl)piperazine (59 mg, 0.312 mmol), DIPEA (82 mL, 0.468 mmol) and NaBH(OAc)3 (198 mg, 0.936 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08372844B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-ccaa25818ab142afb01dc20a44f6d862 |
| 출처 메모 | uspto-grants-2013_02 |