Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2,4-Xylyl)piperazine → 1-(2,4-dimethylphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2,4-Xylyl)piperazine | HCID 70544 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal | HCID 42631135 | — |
| 생성물 | 1-(2,4-dimethylphenyl)-4-(3-(1,5-diphenyl-1H-pyrazol-3-yl)propyl)piperazine | HCID 25065047 | — |
반응 단계
91 mg (64%) of target compound was obtained by using a method same as in Example 1 by using 3-(1,5-diphenyl-1H-pyrazol-3-yl)propanal (80 mg, 0.289 mmol), 1-(2,4-dimethylphenyl)piperazine (55 mg, 0.289 mmol), DIPEA (76 mL, 0.434 mmol) and NaBH(OAc)3 (184 mg, 0.868 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08372844B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-9b6344adcf16460fa39fe2e2d07d4847 |
| 출처 메모 | uspto-grants-2013_02 |