Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl morpholine oxide → 2-Bromo-5-(trifluoromethyl)benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl morpholine oxide | HCID 82029 | — |
| 반응물 | 2-Bromo-5-(trifluoromethyl)benzyl alcohol | HCID 2756248 | — |
| 촉매 | HCID 178419074 | HCID 178419074 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Bromo-5-(trifluoromethyl)benzaldehyde | HCID 7018047 | — |
반응 단계
2-Bromo-5-(trifluoromethyl)benzyl alcohol (2.216 g, 8.69 mmol) and N-methylmorpholine-N-oxide (2.051 g, 17.38 mmol) were combined in CH2Cl2 (44 mL) and MeCN (2.2 mL). Tetrapropylammonium perruthenate (0.311 g, 0.87 mmol) was added, and the reaction was stirred for 20 minutes at room temperature. Once no starting material was seen by analytical tlc, the mixture was concentrated, and the residue was purified by silica gel chromatography to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524748B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-3b24e4b4e1b945c3aacdfacc4a0d6bd9 |
| 출처 메모 | uspto-grants-2013_09 |