Methyl morpholine oxide → 2-Bromo-5-(trifluoromethyl)benzaldehyde

HRID 38702

반응식

HRID 38702 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:3]=1[CH2:4][OH:5].C[N+]1([O-])CCOCC1>C(Cl)Cl.CC#N.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[Br:1][C:2]1[CH:9]=[CH:8][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:6][C:3]=1[CH:4]=[O:5]

참가 물질

6

반응물 2

HCID 82029Methyl morpholine oxideHCID 27562482-Bromo-5-(trifluoromethyl)benzyl alcohol

생성물 1

HCID 70180472-Bromo-5-(trifluoromethyl)benzaldehyde

시약·촉매·용매 3

HCID 178419074HCID 178419074, 화합물촉매HCID 6342Acetonitrile용매HCID 6344Dichloromethane용매

실험 절차

2-Bromo-5-(trifluoromethyl)benzyl alcohol (2.216 g, 8.69 mmol) and N-methylmorpholine-N-oxide (2.051 g, 17.38 mmol) were combined in CH2Cl2 (44 mL) and MeCN (2.2 mL). Tetrapropylammonium perruthenate (0.311 g, 0.87 mmol) was added, and the reaction was stirred for 20 minutes at room temperature. Once no starting material was seen by analytical tlc, the mixture was concentrated, and the residue was purified by silica gel chromatography to give the title compound.

후처리

  1. concentrationthe mixture was concentrated
  2. customthe residue was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-3b24e4b4e1b945c3aacdfacc4a0d6bd9
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524748B2

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