Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Phenylpiperazine → 1-phenyl-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Phenylpiperazine | HCID 7096 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propanal | HCID 86639918 | — |
| 생성물 | 1-phenyl-4-(3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propyl)piperazine | HCID 25065460 | — |
반응 단계
116 mg (89%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-phenyl-5-p-tolyl-1H-pyrazol-3-yl)propanal (80 mg, 0.276 mmol), 1-phenylpiperazine (0.041 mL, 0.276 mmol), DIPEA (0.072 mL, 0.414 mmol) and NaBH(OAc)3 (175 mg, 0.828 mmol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08372844B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-d60dda1e9dfc4c70847dc48204e57b50 |
| 출처 메모 | uspto-grants-2013_02 |