Dimethylamine → [(5-Bromothiophen-2-yl)methyl]dimethylamine

반응식

[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[CH2:12]CC[CH2:9]2)=[CH:4][CH:3]=1.CNC.CO>>[Br:1][C:2]1[S:6][C:5]([CH2:7][N:8]([CH3:12])[CH3:9])=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 674Dimethylamine

HCID 887Methanol

HCID 593327581-[(5-Bromo-2-thienyl)methyl]pyrrolidine

생성물 1

HCID 59332723[(5-Bromothiophen-2-yl)methyl]dimethylamine수율 93%

실험 절차

The above procedure to make 1-[(5-bromo-2-thienyl)methyl]pyrrolidine was repeated except using 2 M dimethylamine in methanol (0.75 mL, 1.5 mmol) to afford 204 mg (93%) of the title compound.

출처 및 근거

ORD 기록: ord-96e9d60ad81b46bab749d344d6b46473
출처 데이터셋: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08372875B2

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