Tetrahydrofuran → 1-(o-Tolyl)-5-phenyl-triazole

HRID 387411

반응식

HRID 387411 반응식
[C:1]1(C)[CH:6]=[CH:5][C:4]([N:7]=[N+:8]=[N-:9])=[CH:3][CH:2]=1.[C:11]1([C:17]#[CH:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH2:19]1COCC1>C[C-]1C(C)=C(C)C(C)=C1C.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.Cl[Ru+]>[C:3]1([CH3:19])[CH:2]=[CH:1][CH:6]=[CH:5][C:4]=1[N:7]1[C:17]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:18][N:9]=[N:8]1

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 10821PhenylacetyleneHCID 1374301-Azido-4-methylbenzene

생성물 1

HCID 684326331-(o-Tolyl)-5-phenyl-triazole수율 51%

시약·촉매·용매 1

HCID 71310463Chlororuthenium(1+) 1,2,3,4,5-pentamethylcyclopenta-2,4-dien-1-ide--triphenylphosphane (1/1/2)촉매

실험 절차

4-Tolyl azide (133 mg, 1 mmol), phenylacetylene (113 mg, 1.1 mmol), Cp*RuCl(PPh3)2 (16 mg, 0.02 mmol, 2 mol %). Solvent: THF, 10 mL, 60° C., 6 hours. Slightly yellow product obtained in 51% yield (120 mg). ESI-MS: m/z 236, [M+H].

후처리

  1. customSlightly yellow product obtained in 51% yield (120 mg)

출처 및 근거

ORD 기록
ord-9d4774a15f234d5e8296945ef84477d4
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372986B2

연결된 노트

불러오는 중…