Acetic Acid → 8-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione

HRID 3877노트

반응식

HRID 3877 반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9](O)=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1.[NH3:23].O.C(O)(=O)C>S(Cl)(Cl)=O.CN(C)C=O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:23])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1

참가 물질

8

반응물 4

HCID 176Acetic AcidHCID 222AmmoniaHCID 962WaterHCID 13532361HCID 13532361, 화합물

생성물 1

HCID 201532438-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione

시약·촉매·용매 3

HCID 6228Dimethylformamide촉매HCID 6228Dimethylformamide용매2회HCID 24386Thionyl Chloride용매2회

실험 절차

A quantity of 2.3 gm of 8-(2-methoxy-4-carboxy-phenyl)-1H,-3H-purin-2,6-dione are refluxed for one hour in 50 ml of thionyl chloride with the addition of 1 drop of dimethylformamide. The excess thionyl chloride is drawn off, and the residue is stirred for 16 hours at ambient temperature with a solution of ammonia in dimethylformamide. The dimethylformamide is drawn off, the remainder is mixed with water and acidified with glacial acetic acid, and the product precipitated is filtered off.

후처리

  1. customthe product precipitated
  2. filtrationis filtered off

출처 및 근거

ORD 기록
ord-6a823073ab7c4f51901f88aec89eb947
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04722929

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