2,4-Difluorophenyl isocyanate → N-(4-(6-Cyano-7-(2-methoxyethoxy)-4-quinolyl)oxy-2-fluorophenyl)-N'-(2,4-difluorophenyl)urea

HRID 387716노트

반응식

HRID 387716 반응식
[NH2:1][C:2]1[CH:25]=[CH:24][C:5]([O:6][C:7]2[C:16]3[C:11](=[CH:12][C:13]([O:19][CH2:20][CH2:21][O:22][CH3:23])=[C:14]([C:17]#[N:18])[CH:15]=3)[N:10]=[CH:9][CH:8]=2)=[CH:4][C:3]=1[F:26].[F:27][C:28]1[CH:33]=[C:32]([F:34])[CH:31]=[CH:30][C:29]=1[N:35]=[C:36]=[O:37]>C1(C)C=CC=CC=1>[C:17]([C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][C:13]=1[O:19][CH2:20][CH2:21][O:22][CH3:23])[N:10]=[CH:9][CH:8]=[C:7]2[O:6][C:5]1[CH:24]=[CH:25][C:2]([NH:1][C:36]([NH:35][C:29]2[CH:30]=[CH:31][C:32]([F:34])=[CH:33][C:28]=2[F:27])=[O:37])=[C:3]([F:26])[CH:4]=1)#[N:18]

참가 물질

4

반응물 2

HCID 5932582,4-Difluorophenyl isocyanateHCID 229362984-(4-Amino-3-fluorophenoxy)-6-cyano-7-(2-methoxyethoxy)quinoline

생성물 1

HCID 22936371N-(4-(6-Cyano-7-(2-methoxyethoxy)-4-quinolyl)oxy-2-fluorophenyl)-N'-(2,4-difluorophenyl)urea

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

4-(4-Amino-3-fluorophenoxy)-6-cyano-7-(2-methoxyethoxy)quinoline (352 mg) was suspended in toluene (20 ml) and the suspension was heated to reflux for dissolution, after which 2,4-difluorophenyl isocyanate (236 μl) was added dropwise and the mixture was heated to reflux for 30 minutes. After cooling, the precipitated solid was filtered out, washed with ether and ethyl acetate and dried to obtain 380 mg of the title compound.

후처리

  1. temperaturethe suspension was heated
  2. temperatureto reflux for dissolution
  3. temperaturethe mixture was heated
  4. temperatureto reflux for 30 minutes
  5. temperatureAfter cooling
  6. filtrationthe precipitated solid was filtered out
  7. washwashed with ether and ethyl acetate
  8. customdried

출처 및 근거

ORD 기록
ord-483b28fb95734c0c88914a23234b087e
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372981B2

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