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Dimethylformamide → N1-Cyclopropyl-5-({2-[(cyclopropylcarbonyl)amino]-4-pyridyl}oxy)-1H-1-indolecarboxamide

HRID 387828
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HRID 387828 반응식
[CH:1]1([NH:4][C:5]([N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][C:17]4[CH:22]=[CH:21][N:20]=[C:19]([N:23](C(C5CC5)=O)[C:24]([CH:26]5[CH2:28][CH2:27]5)=[O:25])[CH:18]=4)=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)=[O:6])[CH2:3][CH2:2]1.[Cl-].[NH4+].CN(C)C=O>C(OCC)(=O)C.O.C(O)C>[CH:1]1([NH:4][C:5]([N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][C:17]4[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]([CH:26]5[CH2:28][CH2:27]5)=[O:25])[CH:18]=4)=[CH:13][CH:14]=3)[CH:9]=[CH:8]2)=[O:6])[CH2:3][CH2:2]1
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참가 물질

7

반응물 3

HCID 6228DimethylformamideHCID 25517Ammonium ChlorideHCID 22936650N1-Cyclopropyl-5-({2-[di(cyclopropylcarbonyl)amino]-4-pyridyl}oxy)-1H-1-indolecarboxamide

생성물 1

HCID 58930818N1-Cyclopropyl-5-({2-[(cyclopropylcarbonyl)amino]-4-pyridyl}oxy)-1H-1-indolecarboxamide수율 41%

시약·촉매·용매 3

HCID 702Ethanol용매
HCID 962Water용매2회
HCID 8857Ethyl Acetate용매

실험 절차

N1-Cyclopropyl-5-({2-[di(cyclopropylcarbonyl)amino]-4-pyridyl}oxy)-1H-1-indolecarboxamide (190 mg), ammonium chloride (660 mg), dimethylformamide (5 ml), water (5 ml) and ethanol (5 ml) were stirred at 100° C. for 1 hour. Water and ethyl acetate were added for extraction, and the extract was washed 6 times with water. After drying over magnesium sulfate, the drying agent was filtered off and the solvent was distilled off under reduced pressure. Ethyl acetate was added to the residue and the precipitated solid was filtered out to obtain 66 mg of a white powder.

후처리

  1. washthe extract was washed 6 times with water
  2. dry with materialAfter drying over magnesium sulfate
  3. filtrationthe drying agent was filtered off
  4. distillationthe solvent was distilled off under reduced pressure
  5. additionEthyl acetate was added to the residue
  6. filtrationthe precipitated solid was filtered out

출처 및 근거

ORD 기록
ord-1a9758f9cbef4401a341bf3b5d9e696c
출처 데이터셋
uspto-grants-2013_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08372981B2

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