Dimethylformamide → (Tetrahydro-2H-pyran-4-yl)acetyl chloride

HRID 38787

반응식

HRID 38787 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([OH:10])=O)[CH2:3][CH2:2]1.CN(C)C=O.C(Cl)(=O)C([Cl:19])=O>ClCCl>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]([Cl:19])=[O:10])[CH2:3][CH2:2]1

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 2773575Tetrahydropyran-4-ylacetic acid

생성물 1

HCID 24229747(Tetrahydro-2H-pyran-4-yl)acetyl chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of tetrahydro-2H-pyran-4-ylacetic acid (89 mg), N,N-dimethyl formamide (1 μL), and dichloromethane (1 mL) was added oxalylchloride (54 μL), and the mixture was stirred at room temperature for 2 hours. The reaction liquid was concentrated under reduced pressure, and then toluene (1 mL) was added thereto, followed by further concentration under reduced pressure, to obtain crude tetrahydro-2H-pyran-4-yl acetyl chloride.

후처리

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure
  3. additiontoluene (1 mL) was added
  4. concentrationfollowed by further concentration under reduced pressure

출처 및 근거

ORD 기록
ord-555ce1cf5e494e17afab4008bd8bce25
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08524727B2

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