Ethanol → 4-(4-Aminophenoxy)-2-butyrylaminopyridine

HRID 387931노트

반응식

HRID 387931 반응식
[C:1]([NH:6][C:7]1[CH:12]=[C:11]([O:13][C:14]2[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=2)[CH:10]=[CH:9][N:8]=1)(=[O:5])[CH2:2][CH2:3][CH3:4].[Cl-].[NH4+].C(O)C.CN(C)C=O>[Fe].O>[NH2:20][C:17]1[CH:16]=[CH:15][C:14]([O:13][C:11]2[CH:10]=[CH:9][N:8]=[C:7]([NH:6][C:1](=[O:5])[CH2:2][CH2:3][CH3:4])[CH:12]=2)=[CH:19][CH:18]=1

참가 물질

7

반응물 4

HCID 702EthanolHCID 6228DimethylformamideHCID 25517Ammonium ChlorideHCID 229366772-Butyroylamino-4-(4-nitrophenoxy)pyridine

생성물 1

HCID 229364634-(4-Aminophenoxy)-2-butyrylaminopyridine

시약·촉매·용매 2

HCID 23925Iron촉매HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 0.6 g of 2-butyrylamino-4-(4-nitrophenoxy)pyridine, 1.2 g of iron powder, 2.8 g of ammonium chloride, 10 ml of ethanol, 10 ml of dimethylformamide and 5 ml of water was vigorously stirred at 100° C. for 10 minutes. The reaction was filtered with celite, the solvent was distilled off under reduced pressure, and then water was added to the filtrate and extraction was performed with ethyl acetate. The extract was dried over magnesium sulfate and the solvent distilled off under reduced pressure to obtain 0.6 g of the target substance as a light yellow solid.

후처리

  1. filtrationThe reaction was filtered with celite
  2. distillationthe solvent was distilled off under reduced pressure
  3. additionwater was added to the filtrate and extraction
  4. dry with materialThe extract was dried over magnesium sulfate
  5. distillationthe solvent distilled off under reduced pressure
  6. customto obtain 0.6 g of the target substance as a light yellow solid

출처 및 근거

ORD 기록
ord-fbf189f6177642c09de1423dc7d6e9e0
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372981B2

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