Toluene → N-(4-[(7-cyano-6-methoxy-4-quinolyl)oxy]phenyl)-N'-(4-fluorophenyl)urea

HRID 387959노트

반응식

HRID 387959 반응식
C1(C)C=CC=CC=1.[F:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]=[C:16]=[O:17])=[CH:11][CH:10]=1.[NH2:18][C:19]1[CH:39]=[CH:38][C:22]([O:23][C:24]2[C:33]3[C:28](=[CH:29][C:30]([C:36]#[N:37])=[C:31]([O:34][CH3:35])[CH:32]=3)[N:27]=[CH:26][CH:25]=2)=[CH:21][CH:20]=1>C(#N)C>[C:36]([C:30]1[CH:29]=[C:28]2[C:33]([C:24]([O:23][C:22]3[CH:38]=[CH:39][C:19]([NH:18][C:16]([NH:15][C:12]4[CH:13]=[CH:14][C:9]([F:8])=[CH:10][CH:11]=4)=[O:17])=[CH:20][CH:21]=3)=[CH:25][CH:26]=[N:27]2)=[CH:32][C:31]=1[O:34][CH3:35])#[N:37]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 709554-Fluorophenyl isocyanateHCID 22936943HCID 22936943, 화합물

생성물 1

HCID 67204014N-(4-[(7-cyano-6-methoxy-4-quinolyl)oxy]phenyl)-N'-(4-fluorophenyl)urea

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

After adding toluene (5 ml), acetonitrile (1.5 ml) and 4-fluorophenyl isocyanate (0.105 ml) to 4-(4-aminophenoxy)-6-methoxyquinoline-7-carbonitrile (180 mg), the mixture was heated to reflux for 30 minutes. The mixture was cooled, and the precipitated crystals were filtered out and washed with toluene to obtain the title compound (230 mg) as light yellow crystals.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 30 minutes
  3. temperatureThe mixture was cooled
  4. filtrationthe precipitated crystals were filtered out
  5. washwashed with toluene

출처 및 근거

ORD 기록
ord-29e0e94f7edf4d658e6f3db149d5272b
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372981B2

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