Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1H-Benzotriazole-1-methanol → N-{1-(1H-Benzotriazolyl)methyl}-4-benzyloxy-2-fluoroaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1H-Benzotriazole-1-methanol | HCID 224169 | — |
| 반응물 | 4-(Benzyloxy)-2-fluoroaniline | HCID 11499809 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | N-{1-(1H-Benzotriazolyl)methyl}-4-benzyloxy-2-fluoroaniline | HCID 22936313 | 66.6% |
반응 단계
After dissolving 4-benzyloxy-2-fluoroaniline (11.25 g, 51.78 mmol) in methanol (300 ml), 1H-benzotriazole-1-methanol (8.11 g, 54.37 mmol) was added and the mixture was stirred for 10 hours at room temperature. The precipitated crystals were filtered out, washed with ethanol and dried by aspiration to obtain the title compound (12.01 g, 34.47 mmol, 66.57%) as colorless crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08372981B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-cc5446e4087a46568ebdea5815b005e6 |
| 출처 메모 | uspto-grants-2013_02 |